The Kinesin Light Chain-Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes.
Identifieur interne : 000515 ( Main/Exploration ); précédent : 000514; suivant : 000516The Kinesin Light Chain-Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes.
Auteurs : Riad Arabi-Derkawi [France] ; Yvonne O'Dowd [France, Irlande (pays)] ; Ni Cheng [États-Unis] ; Loïc Rolas [France] ; Tarek Boussetta [France] ; Houssam Raad [France] ; Viviana Marzaioli [France] ; Coralie Pintard [France] ; Magali Fasseu [France] ; Yolande Kroviarski [France] ; Sahra A. Belambri [France, Algérie] ; Pham My-Chan Dang [France] ; Richard D. Ye [États-Unis] ; Marie-Anne Gougerot-Pocidalo [France] ; Jamel El-Benna [France]Source :
- Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2019.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN messager (métabolisme), Anions (métabolisme), Humains (MeSH), Phagocytes (métabolisme), Superoxydes (métabolisme), Symporteurs (génétique), Symporteurs (métabolisme), Systèmes de transport d'acides aminés (génétique), Systèmes de transport d'acides aminés (métabolisme).
- MESH :
- génétique : ARN messager, Symporteurs, Systèmes de transport d'acides aminés.
- métabolisme : ARN messager, Anions, Phagocytes, Superoxydes, Symporteurs, Systèmes de transport d'acides aminés.
- Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Amino Acid Transport Systems, RNA, Messenger, Symporters.
- chemical , metabolism : Amino Acid Transport Systems, Anions, RNA, Messenger, Superoxides, Symporters.
- metabolism : Phagocytes.
- Humans.
Abstract
Superoxide anion production by the phagocyte NADPH oxidase plays a crucial role in host defenses and inflammatory reaction. The phagocyte NADPH oxidase is composed of cytosolic components (p40phox, p47phox, p67phox, and Rac1/2) and the membrane flavocytochrome b558, which is composed of two proteins: p22phox and gp91phox/NOX2. p22phox plays a crucial role in the stabilization of gp91phox in phagocytes and is also a docking site for p47phox during activation. In the current study, we have used a yeast two-hybrid approach to identify unknown partners of p22phox. Using the cytosolic C-terminal region of p22phox as bait to screen a human spleen cDNA library, we identified the protein interacting with amyloid precursor protein tail 1 (PAT1) as a potential partner of p22phox. The interaction between p22phox and PAT1 was further confirmed by in vitro GST pulldown and overlay assays and in intact neutrophils and COSphox cells by coimmunoprecipitation. We demonstrated that PAT1 is expressed in human neutrophils and monocytes and colocalizes with p22phox, as shown by confocal microscopy. Overexpression of PAT1 in human monocytes and in COSphox cells increased superoxide anion production and depletion of PAT1 by specific small interfering RNA inhibited this process. These data clearly identify PAT1 as a novel regulator of NADPH oxidase activation and superoxide anion production, a key phagocyte function.
DOI: 10.4049/jimmunol.1800610
PubMed: 30665935
Affiliations:
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Le document en format XML
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Ye</name><affiliation wicri:level="2"><nlm:affiliation>University of Illinois College of Medicine, Chicago, IL 60612; and.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Illinois College of Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Gougerot Pocidalo, Marie Anne" sort="Gougerot Pocidalo, Marie Anne" uniqKey="Gougerot Pocidalo M" first="Marie-Anne" last="Gougerot-Pocidalo">Marie-Anne Gougerot-Pocidalo</name><affiliation wicri:level="3"><nlm:affiliation>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Unité Fonctionnelle Dysfonctionnements Immunitaires, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Xavier Bichat, Paris, F-75018, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité Fonctionnelle Dysfonctionnements Immunitaires, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Xavier Bichat, Paris, F-75018</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="El Benna, Jamel" sort="El Benna, Jamel" uniqKey="El Benna J" first="Jamel" last="El-Benna">Jamel El-Benna</name><affiliation wicri:level="3"><nlm:affiliation>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris, France; jamel.elbenna@inserm.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30665935</idno><idno type="pmid">30665935</idno><idno type="doi">10.4049/jimmunol.1800610</idno><idno type="wicri:Area/PubMed/Corpus">000293</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000293</idno><idno type="wicri:Area/PubMed/Curation">000292</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000292</idno><idno type="wicri:Area/PubMed/Checkpoint">000211</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" 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wicri:level="3"><nlm:affiliation>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Unité Fonctionnelle Dysfonctionnements Immunitaires, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Xavier Bichat, Paris, F-75018, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité Fonctionnelle Dysfonctionnements Immunitaires, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Xavier Bichat, Paris, F-75018</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="O Dowd, Yvonne" sort="O Dowd, Yvonne" uniqKey="O Dowd Y" first="Yvonne" last="O'Dowd">Yvonne O'Dowd</name><affiliation wicri:level="3"><nlm:affiliation>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Garda Headquarters, Forensic Science Ireland, Dublin 8, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Garda Headquarters, Forensic Science Ireland, Dublin 8</wicri:regionArea><wicri:noRegion>Dublin 8</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, Ni" sort="Cheng, Ni" uniqKey="Cheng N" first="Ni" last="Cheng">Ni Cheng</name><affiliation wicri:level="2"><nlm:affiliation>University of Illinois College of Medicine, Chicago, IL 60612; and.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Illinois College of Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Rolas, Loic" sort="Rolas, Loic" uniqKey="Rolas L" first="Loïc" last="Rolas">Loïc Rolas</name><affiliation wicri:level="3"><nlm:affiliation>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Boussetta, Tarek" sort="Boussetta, Tarek" uniqKey="Boussetta T" first="Tarek" last="Boussetta">Tarek Boussetta</name><affiliation wicri:level="3"><nlm:affiliation>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Raad, Houssam" sort="Raad, Houssam" uniqKey="Raad H" first="Houssam" last="Raad">Houssam Raad</name><affiliation wicri:level="3"><nlm:affiliation>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Marzaioli, Viviana" sort="Marzaioli, Viviana" uniqKey="Marzaioli V" first="Viviana" last="Marzaioli">Viviana Marzaioli</name><affiliation wicri:level="3"><nlm:affiliation>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pintard, Coralie" sort="Pintard, Coralie" uniqKey="Pintard C" first="Coralie" last="Pintard">Coralie Pintard</name><affiliation wicri:level="3"><nlm:affiliation>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Fasseu, Magali" sort="Fasseu, Magali" uniqKey="Fasseu M" first="Magali" last="Fasseu">Magali Fasseu</name><affiliation wicri:level="3"><nlm:affiliation>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kroviarski, Yolande" sort="Kroviarski, Yolande" uniqKey="Kroviarski Y" first="Yolande" last="Kroviarski">Yolande Kroviarski</name><affiliation wicri:level="3"><nlm:affiliation>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Belambri, Sahra A" sort="Belambri, Sahra A" uniqKey="Belambri S" first="Sahra A" last="Belambri">Sahra A. Belambri</name><affiliation wicri:level="3"><nlm:affiliation>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université Ferhat Abbas, 19000 Sétif, Algeria.</nlm:affiliation><country xml:lang="fr">Algérie</country><wicri:regionArea>Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université Ferhat Abbas, 19000 Sétif</wicri:regionArea><wicri:noRegion>19000 Sétif</wicri:noRegion></affiliation></author><author><name sortKey="Dang, Pham My Chan" sort="Dang, Pham My Chan" uniqKey="Dang P" first="Pham My-Chan" last="Dang">Pham My-Chan Dang</name><affiliation wicri:level="3"><nlm:affiliation>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ye, Richard D" sort="Ye, Richard D" uniqKey="Ye R" first="Richard D" last="Ye">Richard D. Ye</name><affiliation wicri:level="2"><nlm:affiliation>University of Illinois College of Medicine, Chicago, IL 60612; and.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Illinois College of Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Gougerot Pocidalo, Marie Anne" sort="Gougerot Pocidalo, Marie Anne" uniqKey="Gougerot Pocidalo M" first="Marie-Anne" last="Gougerot-Pocidalo">Marie-Anne Gougerot-Pocidalo</name><affiliation wicri:level="3"><nlm:affiliation>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Unité Fonctionnelle Dysfonctionnements Immunitaires, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Xavier Bichat, Paris, F-75018, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité Fonctionnelle Dysfonctionnements Immunitaires, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Xavier Bichat, Paris, F-75018</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="El Benna, Jamel" sort="El Benna, Jamel" uniqKey="El Benna J" first="Jamel" last="El-Benna">Jamel El-Benna</name><affiliation wicri:level="3"><nlm:affiliation>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris, France; jamel.elbenna@inserm.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>INSERM-U1149, CNRS-ERL8252, Centre de Recherche sur l'Inflammation, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Excellence Inflamex, Faculté de Médecine, Site Xavier Bichat, Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title><idno type="eISSN">1550-6606</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Transport Systems (genetics)</term><term>Amino Acid Transport Systems (metabolism)</term><term>Anions (metabolism)</term><term>Humans (MeSH)</term><term>Phagocytes (metabolism)</term><term>RNA, Messenger (genetics)</term><term>RNA, Messenger (metabolism)</term><term>Superoxides (metabolism)</term><term>Symporters (genetics)</term><term>Symporters (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term><term>ARN messager (métabolisme)</term><term>Anions (métabolisme)</term><term>Humains (MeSH)</term><term>Phagocytes (métabolisme)</term><term>Superoxydes (métabolisme)</term><term>Symporteurs (génétique)</term><term>Symporteurs (métabolisme)</term><term>Systèmes de transport d'acides aminés (génétique)</term><term>Systèmes de transport d'acides aminés (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Amino Acid Transport Systems</term><term>RNA, Messenger</term><term>Symporters</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amino Acid Transport Systems</term><term>Anions</term><term>RNA, Messenger</term><term>Superoxides</term><term>Symporters</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>Symporteurs</term><term>Systèmes de transport d'acides aminés</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Phagocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term><term>Anions</term><term>Phagocytes</term><term>Superoxydes</term><term>Symporteurs</term><term>Systèmes de transport d'acides aminés</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Superoxide anion production by the phagocyte NADPH oxidase plays a crucial role in host defenses and inflammatory reaction. The phagocyte NADPH oxidase is composed of cytosolic components (p40phox, p47phox, p67phox, and Rac1/2) and the membrane flavocytochrome b558, which is composed of two proteins: p22phox and gp91phox/NOX2. p22phox plays a crucial role in the stabilization of gp91phox in phagocytes and is also a docking site for p47phox during activation. In the current study, we have used a yeast two-hybrid approach to identify unknown partners of p22phox. Using the cytosolic C-terminal region of p22phox as bait to screen a human spleen cDNA library, we identified the protein interacting with amyloid precursor protein tail 1 (PAT1) as a potential partner of p22phox. The interaction between p22phox and PAT1 was further confirmed by in vitro GST pulldown and overlay assays and in intact neutrophils and COSphox cells by coimmunoprecipitation. We demonstrated that PAT1 is expressed in human neutrophils and monocytes and colocalizes with p22phox, as shown by confocal microscopy. Overexpression of PAT1 in human monocytes and in COSphox cells increased superoxide anion production and depletion of PAT1 by specific small interfering RNA inhibited this process. These data clearly identify PAT1 as a novel regulator of NADPH oxidase activation and superoxide anion production, a key phagocyte function.</div></front></TEI><affiliations><list><country><li>Algérie</li><li>France</li><li>Irlande (pays)</li><li>États-Unis</li></country><region><li>Illinois</li><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Arabi Derkawi, Riad" sort="Arabi Derkawi, Riad" uniqKey="Arabi Derkawi R" first="Riad" last="Arabi-Derkawi">Riad Arabi-Derkawi</name></region><name sortKey="Arabi Derkawi, Riad" sort="Arabi Derkawi, Riad" uniqKey="Arabi Derkawi R" first="Riad" last="Arabi-Derkawi">Riad Arabi-Derkawi</name><name sortKey="Arabi Derkawi, Riad" sort="Arabi Derkawi, Riad" uniqKey="Arabi Derkawi R" first="Riad" last="Arabi-Derkawi">Riad Arabi-Derkawi</name><name sortKey="Belambri, Sahra A" sort="Belambri, Sahra A" uniqKey="Belambri S" first="Sahra A" last="Belambri">Sahra A. Belambri</name><name sortKey="Belambri, Sahra A" sort="Belambri, Sahra A" uniqKey="Belambri S" first="Sahra A" last="Belambri">Sahra A. Belambri</name><name sortKey="Boussetta, Tarek" sort="Boussetta, Tarek" uniqKey="Boussetta T" first="Tarek" last="Boussetta">Tarek Boussetta</name><name sortKey="Boussetta, Tarek" sort="Boussetta, Tarek" uniqKey="Boussetta T" first="Tarek" last="Boussetta">Tarek Boussetta</name><name sortKey="Dang, Pham My Chan" sort="Dang, Pham My Chan" uniqKey="Dang P" first="Pham My-Chan" last="Dang">Pham My-Chan Dang</name><name sortKey="Dang, Pham My Chan" sort="Dang, Pham My Chan" uniqKey="Dang P" first="Pham My-Chan" last="Dang">Pham My-Chan Dang</name><name sortKey="El Benna, Jamel" sort="El Benna, Jamel" uniqKey="El Benna J" first="Jamel" last="El-Benna">Jamel El-Benna</name><name sortKey="El Benna, Jamel" sort="El Benna, Jamel" uniqKey="El Benna J" first="Jamel" last="El-Benna">Jamel El-Benna</name><name sortKey="Fasseu, Magali" sort="Fasseu, Magali" uniqKey="Fasseu M" first="Magali" last="Fasseu">Magali Fasseu</name><name sortKey="Fasseu, Magali" sort="Fasseu, Magali" uniqKey="Fasseu M" first="Magali" last="Fasseu">Magali Fasseu</name><name sortKey="Gougerot Pocidalo, Marie Anne" sort="Gougerot Pocidalo, Marie Anne" uniqKey="Gougerot Pocidalo M" first="Marie-Anne" last="Gougerot-Pocidalo">Marie-Anne Gougerot-Pocidalo</name><name sortKey="Gougerot Pocidalo, Marie Anne" sort="Gougerot Pocidalo, Marie Anne" uniqKey="Gougerot Pocidalo M" first="Marie-Anne" last="Gougerot-Pocidalo">Marie-Anne Gougerot-Pocidalo</name><name sortKey="Gougerot Pocidalo, Marie Anne" sort="Gougerot Pocidalo, Marie Anne" uniqKey="Gougerot Pocidalo M" first="Marie-Anne" last="Gougerot-Pocidalo">Marie-Anne Gougerot-Pocidalo</name><name sortKey="Kroviarski, Yolande" sort="Kroviarski, Yolande" uniqKey="Kroviarski Y" first="Yolande" last="Kroviarski">Yolande Kroviarski</name><name sortKey="Kroviarski, Yolande" sort="Kroviarski, Yolande" uniqKey="Kroviarski Y" first="Yolande" last="Kroviarski">Yolande Kroviarski</name><name sortKey="Marzaioli, Viviana" sort="Marzaioli, Viviana" uniqKey="Marzaioli V" first="Viviana" last="Marzaioli">Viviana Marzaioli</name><name sortKey="Marzaioli, Viviana" sort="Marzaioli, Viviana" uniqKey="Marzaioli V" first="Viviana" last="Marzaioli">Viviana Marzaioli</name><name sortKey="O Dowd, Yvonne" sort="O Dowd, Yvonne" uniqKey="O Dowd Y" first="Yvonne" last="O'Dowd">Yvonne O'Dowd</name><name sortKey="O Dowd, Yvonne" sort="O Dowd, Yvonne" uniqKey="O Dowd Y" first="Yvonne" last="O'Dowd">Yvonne O'Dowd</name><name sortKey="Pintard, Coralie" sort="Pintard, Coralie" uniqKey="Pintard C" first="Coralie" last="Pintard">Coralie Pintard</name><name sortKey="Pintard, Coralie" sort="Pintard, Coralie" uniqKey="Pintard C" first="Coralie" last="Pintard">Coralie Pintard</name><name sortKey="Raad, Houssam" sort="Raad, Houssam" uniqKey="Raad H" first="Houssam" last="Raad">Houssam Raad</name><name sortKey="Raad, Houssam" sort="Raad, Houssam" uniqKey="Raad H" first="Houssam" last="Raad">Houssam Raad</name><name sortKey="Rolas, Loic" sort="Rolas, Loic" uniqKey="Rolas L" first="Loïc" last="Rolas">Loïc Rolas</name><name sortKey="Rolas, Loic" sort="Rolas, Loic" uniqKey="Rolas L" first="Loïc" last="Rolas">Loïc Rolas</name></country><country name="Irlande (pays)"><noRegion><name sortKey="O Dowd, Yvonne" sort="O Dowd, Yvonne" uniqKey="O Dowd Y" first="Yvonne" last="O'Dowd">Yvonne O'Dowd</name></noRegion></country><country name="États-Unis"><region name="Illinois"><name sortKey="Cheng, Ni" sort="Cheng, Ni" uniqKey="Cheng N" first="Ni" last="Cheng">Ni Cheng</name></region><name sortKey="Ye, Richard D" sort="Ye, Richard D" uniqKey="Ye R" first="Richard D" last="Ye">Richard D. Ye</name></country><country name="Algérie"><noRegion><name sortKey="Belambri, Sahra A" sort="Belambri, Sahra A" uniqKey="Belambri S" first="Sahra A" last="Belambri">Sahra A. Belambri</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= The Kinesin Light Chain-Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes.
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